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| StepanovichAzat | Дата: Вторник, 29.10.2013, 01:34 | Сообщение # 2 |
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| famuyiyaok | Дата: Четверг, 09.04.2015, 21:08 | Сообщение # 5 |
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Группа: Гости
| Varenicline (swop name Chantix in the USA and Champix in Canada, Europe and other countries, marketed close to Pfizer, predominantly in the practice of varenicline tartrate), is a prescription medication habituated to to survey nicotine addiction. Varenicline is a nicotinic receptor affinity to agonist—it stimulates nicotine receptors more weakly than nicotine itself does. In this respect it is comparable tocytisine and conflicting from the nicotinic contender, bupropion, and nicotine replacement therapies (NRTs) like nicotine patchesand nicotine gum. As a affinity to agonist it both reduces cravings against and decreases the pleasurable effects of cigarettes and other tobacco products. Result of these mechanisms it can work for some patients to relinquish smoking.
Medical uses
Varenicline is indicated for smoking cessation. In a 2006 randomized controlled hearing sponsored by Pfizer, after anyone year the charge of continuous abstinence was 10% in the interest placebo, 15% instead of bupropion and 23% benefit of varenicline.[1 - In a 2009 meta-analysis of 101 studies funded via Pfizer, varenicline was start to be more effectual than bupropion (odds relationship 1.40) and NRTs (odds correlation 1.56).[2 -
A Cochrane systematic notice concluded that varenicline improved the strong of successfully quitting smoking by means of two- to three-fold proportionate to pharmacologically unassisted attempts. Varenicline was more productive than bupropion in this appreciation but not statistically high-class to NRT.[3 -
The FDA has approved the ingest of varenicline in requital for up to twelve weeks. If smoking cessation has been achieved it may be continued in requital for another twelve weeks.[4 -
Varenicline has not been tested in those junior to 18 years prehistoric or in the pudding club women and that being so is not recommended in behalf of spurn aside these groups.
Adverse effects
Nausea occurs commonly in people winning varenicline. Other less common side effects subsume cephalalgia, difficulty sleeping, and psych jargon exceptional dreams. Rare side effects reported by people entrancing varenicline compared to placebo cover change in decorum, vomiting,abdominal soreness, flatulence, and constipation. In a recent meta-analysis ownership papers by Leung et al., it has been estimated that for every five subjects bewitching varenicline at maintenance doses (1 mg twice common), there resolution be an actuality of nausea, and for every 24 and 35 treated subjects, there wishes be an conclusion of constipation and flatulence respectively. Gastrointestinal side-effects are portentous factors compromising the compliance of varenicline.[5 - [6 -
Depression and suicide
In November 2007, the FDA announced it had received post-marketing reports that patients using varenicline as a service to smoking cessation had knowing not too important side-effects, including suicidal ideation and infrequent suicidal behavior, haphazard behavior, and drowsiness. On February 1, 2008 the FDA issued an heedful to fresh make plain its findings, noting that "it appears increasingly likely that there is an intimacy between Chantix and acute neuropsychiatric symptoms". It is anonymous whether the psychiatric symptoms are linked to the psychedelic or to nicotine withdrawal symptoms,[citation needed - although not all patients had stopped smoking. The FDA also recommended that healthiness vigilance professionals and patients notice fitted behavioral and mood changes.[7 - In May 2008, Pfizer updated the shelter intelligence associated with varenicline, noting that "some patients have reported changes in behavior, incitement, depressed mood, suicidal thoughts or actions."[8 -
As of July 1, 2009, the US Food and Narcotic Provision requires Chantix (varenicline) to lug a swart crate warning, the action's strongest safeness warning, justified to public reports of side effects including depression, suicidal thoughts, and suicidal actions.[9 -
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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